StressCovidV1, France, Analysis, bibRecord, 000211

Can bipolar disorder be viewed as a multi-system inflammatory disease?

Identifieur interne : 000211 ( France/Analysis ); précédent : 000210; suivant : 000212

Can bipolar disorder be viewed as a multi-system inflammatory disease?

Auteurs : Marion Leboyer [France, États-Unis] ; Isabella Soreca [États-Unis] ; Jan Scott [France, Royaume-Uni] ; Mark Frye [États-Unis] ; Chantal Henry [France, États-Unis] ; Ryad Tamouza [France] ; David J. Kupfer [États-Unis]

Source :

Journal of affective disorders [ 0165-0327 ] ; 2012.

RBID : Pascal:12-0374366

Descripteurs français

Pascal (Inist)
- Trouble bipolaire, Maladie inflammatoire, Pathologie de l'appareil circulatoire, Mortalité, Inflammation, Prévention, Santé publique.
Wicri :
- topic : Mortalité, Santé publique.

English descriptors

KwdEn :
- Bipolar disorder, Cardiovascular disease, Inflammation, Inflammatory disease, Mortality, Prevention, Public health.

Abstract

Background: Patients with bipolar disorder are known to be at high risk of premature death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well above the risk associated with suicide. In this review, we explore comorbid medical disorders, highlighting evidence that bipolar disorder can be effectively conceptualized as a multi-systemic inflammatory disease. Methods: We conducted a systematic PubMed search of all English-language articles recently published with bipolar disorder cross-referenced with the following terms: mortality and morbidity, cardio-vascular, diabetes, obesity, metabolic syndrome, inflammation, auto-antibody, retro-virus, stress, sleep and circadian rhythm. Results: Evidence gathered so far suggests that the multi-system involvement is present from the early stages, and therefore requires proactive screening and diagnostic procedures, as well as comprehensive treatment to reduce progression and premature mortality. Exploring the biological pathways that could account for the observed link show that dysregulated inflammatory background could be a common factor underlying cardio-vascular and bipolar disorders. Viewing bipolar disorder as a multi-system disorder should help us to re-conceptualize disorders of the mind as "disorders of the brain and the body". Limitations: The current literature substantially lacks longitudinal and mechanistic studies, as well as comparison studies to explore the magnitude of the medical burden in bipolar disorder compared to major mood disorders as well as psychotic disorders. It is also necessary to look for subgroups of bipolar disorder based on their rates of comorbid disorders. Conclusions: Comorbid medical illnesses in bipolar disorder might be viewed not only as the consequence of health behaviors and of psychotropic medications, but rather as an early manifestation of a multi-systemic disorder. Medical monitoring is thus a critical component of case assessment Exploring common biological pathways of inflammation should help biomarkers discovery, ultimately leading to innovative diagnostic tools, new methods of prevention and personalized treatments.

Affiliations:

Links to Exploration step

Pascal:12-0374366

Le document en format XML

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<term>Inflammation</term>
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<front><div type="abstract" xml:lang="en">Background: Patients with bipolar disorder are known to be at high risk of premature death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well above the risk associated with suicide. In this review, we explore comorbid medical disorders, highlighting evidence that bipolar disorder can be effectively conceptualized as a multi-systemic inflammatory disease. Methods: We conducted a systematic PubMed search of all English-language articles recently published with bipolar disorder cross-referenced with the following terms: mortality and morbidity, cardio-vascular, diabetes, obesity, metabolic syndrome, inflammation, auto-antibody, retro-virus, stress, sleep and circadian rhythm. Results: Evidence gathered so far suggests that the multi-system involvement is present from the early stages, and therefore requires proactive screening and diagnostic procedures, as well as comprehensive treatment to reduce progression and premature mortality. Exploring the biological pathways that could account for the observed link show that dysregulated inflammatory background could be a common factor underlying cardio-vascular and bipolar disorders. Viewing bipolar disorder as a multi-system disorder should help us to re-conceptualize disorders of the mind as "disorders of the brain and the body". Limitations: The current literature substantially lacks longitudinal and mechanistic studies, as well as comparison studies to explore the magnitude of the medical burden in bipolar disorder compared to major mood disorders as well as psychotic disorders. It is also necessary to look for subgroups of bipolar disorder based on their rates of comorbid disorders. Conclusions: Comorbid medical illnesses in bipolar disorder might be viewed not only as the consequence of health behaviors and of psychotropic medications, but rather as an early manifestation of a multi-systemic disorder. Medical monitoring is thus a critical component of case assessment Exploring common biological pathways of inflammation should help biomarkers discovery, ultimately leading to innovative diagnostic tools, new methods of prevention and personalized treatments.</div>
</front>
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<country name="Royaume-Uni"><noRegion><name sortKey="Scott, Jan" sort="Scott, Jan" uniqKey="Scott J" first="Jan" last="Scott">Jan Scott</name>
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Can bipolar disorder be viewed as a multi-system inflammatory disease?

Can bipolar disorder be viewed as a multi-system inflammatory disease?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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